Multi-scale surface topography to minimize adherence and viability of nosocomial drug-resistant bacteria

Multi-scale surface topography to minimize adherence and viability of nosocomial drug-resistant bacteria

Blog Article

Toward minimizing bacterial colonization of surfaces, we present a one-step etching technique that renders aluminum alloys with micro- and nano-scale roughness.Such a multi-scale surface topography exhibited enhanced antibacterial effect against a wide range of pathogens.Multi-scale topography of commercially grade pure aluminum killed 97% of Escherichia coli and 28% of Staphylococcus aureus cells in comparison to 7% and 3%, Reception Desks respectively, on the smooth surfaces.Multi-scale topography on Al 5052 surface was shown to kill 94% of adhered E.coli cells.

The microscale features on the etched Al 1200 alloy were not found to be significantly bactericidal, but shown to decrease the adherence of S.aureus cells by one-third.The fabrication method is easily scalable for industrial applications.Analysis of roughness parameters determined by atomic force microscopy revealed a set of significant parameters that can yield a highly bactericidal surface; thereby providing the USB Card Reader design to make any surface bactericidal irrespective of the method of fabrication.The multi-scale roughness of Al 5052 alloy was also highly bactericidal to nosocomial isolates of E.

coli, K.pneumoniae and P.aeruginosa.We envisage the potential application of engineered surfaces with multi-scale topography to minimize the spread of nosocomial infections.Keywords: Wet etching, Nanotopography, Biofilm, Antifouling, Bactericidal, Nosocomial infections, Drug resistant bacteria.